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目的研究视网膜母细胞瘤（ｒｅｔｉｎｏｂｌａｓｔｏｍａ，ＲＢ）细胞分化程度与转移的关系，探讨其对预后的影响。方法对１５４例ＲＢ病人的眼球标本进行组织病理学观察，比较分化型与未分化型ＲＢ二者肿瘤细胞转移比率、转移程度及平均确诊年龄。结果分化型ＲＢ的转移发生率为４７．０６％，未分化型为４６．７２％，但后者转移的严重程度高于前者。发生转移的细胞均为未分化细胞。分化型ＲＢ平均确诊年龄为９．４３月，未分化型为４０．５８月。结论分化型与未分化型ＲＢ的转移比率相似，但未分化型转移程度更重。肿瘤细胞在眼内存留时间越长，分化越差。
Objective To study the relationship between the degree of cell differentiation and metastasis of retinoblastoma (RB) and its influence on the prognosis. Methods The eyeball specimens of 154 patients with RB were observed histopathologically. The metastasis rate, metastasis rate and mean age at diagnosis of differentiated and undifferentiated RB were compared. Results The incidence of metastasis of differentiated RB was 47.06%, undifferentiated 46.72%, but the latter was more serious than the former. The cells that have metastasized are undifferentiated cells. The mean age at diagnosis of differentiated RB was 9.43 months and undifferentiated age was 40.58 months. Conclusions The rates of metastasis of differentiated and undifferentiated RBs are similar, but undifferentiated metastasis is more serious. Tumor cells in the eye retention longer, the worse the worse.