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目的探讨丙种球蛋白联合地塞米松在小儿特发性血小板减少性紫癜中的疗效。方法选取2009年1月～2011年1月于某院进行治疗的80例小儿特发性血小板减少性紫癜患者为研究对象,将其随机分为对照组(地塞米松组)40例和观察组(丙种球蛋白联合地塞米松组)40例,后将两组患者的治疗总有效率、不良反应发生率及治疗前后的外周血T淋巴细胞亚群、IL-6、TNF-α及IL-18水平进行统计及比较。结果观察组的治疗总有效率高于对照组,CD3+、CD4+、CD4+/CD8+水平高于对照组,CD8+、IL-6、TNF-α及IL-18水平低于对照组,P﹤0.05或P﹤0.01,有显著性或非常显著性差异,但不良反应发生率差异无统计学意义,P﹥0.05。结论丙种球蛋白联合地塞米松在小儿特发性血小板减少性紫癜中的疗效显著,可调节患者的免疫状态,优势明显。
Objective To investigate the efficacy of gamma globulin combined with dexamethasone in children with idiopathic thrombocytopenic purpura. Methods Eighty children with idiopathic thrombocytopenic purpura treated in a hospital from January 2009 to January 2011 were selected as study subjects and randomly divided into control group (dexamethasone group) 40 cases and observation group (Gamma globulin combined with dexamethasone group) 40 cases, then the two groups of patients with total effective rate, the incidence of adverse reactions and before and after treatment of peripheral blood T lymphocyte subsets, IL-6, TNF- and IL- 18 levels for statistics and comparison. Results The total effective rate of observation group was higher than that of control group, the level of CD3 +, CD4 +, CD4 + / CD8 + was higher than that of control group, and the levels of CD8 +, IL-6, TNF- and IL- <0.01, significant or very significant differences, but the incidence of adverse reactions was no significant difference, P> 0.05. Conclusion Gamma globulin combined with dexamethasone in children with idiopathic thrombocytopenic purpura significant effect, can regulate the immune status of patients with obvious advantages.