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近年自然流产呈上升趋势,调查发现自发性流产与工作或生活环境中接触的有害物质相关。有害暴露可发生在孕前对精子/卵子的损伤[1-2],或受精后对胚胎发育的影响。孕2~8周是胚胎器官形成期,对环境毒物的影响非常敏感,因此自然流产多发生在孕早期,包括孕6周前的流产在内,孕早期流产率可高达30%以上[2]。围孕期暴露农药等环境毒物不仅会影响胎儿宫内发育,导致自然流产、早产、先天畸形
In recent years, there has been an increase in spontaneous abortion. The survey found that spontaneous abortion is related to harmful substances in contact with work or living environment. Harmful exposure can occur on sperm / egg damage prior to pregnancy [1-2], or on the embryonic development after fertilization. Pregnancy 2 to 8 weeks is the formation of embryonic organs, the impact of environmental toxicants is very sensitive, so spontaneous abortion occurs in early pregnancy, including abortion 6 weeks before pregnancy, abortion rate in early pregnancy can be as high as 30% or more [2] . Perinatal exposure to pesticides and other environmental toxicants will not only affect fetal intrauterine growth, leading to spontaneous abortion, premature birth, congenital malformations