盐酸氨溴索联合NCPAP治疗新生儿呼吸窘迫综合征疗效观察

• 作 者: 巫健明
• 机 构: 广东省五华县人民医院新生儿科,
• 出 处: 中国实用医药
• 发表日期: 2010年13期
• 关键词: 持续正压通气 盐酸氨溴索 新生儿呼吸窘迫综合征

目的评价经鼻持续正压通气(NCPAP)及盐酸氨溴索联合治疗新生儿呼吸窘迫综合征(NRDS)的治疗效果,并与常规机械通气对照。方法对52例NRDS患儿进行临床观察,随机分为两组,治疗组及观察组各26例,治疗组予盐酸氨溴索联合NCPAP治疗,观察组常规使用机械通气。对照指标:临床症状及体征、血气分析、氧疗时间、并发症。结果两组在治疗后24、48h,临床症状、体征及血气分析较治疗前显著改善,无明显差异,但治疗组肺部感染等并发症及氧疗时间均少于观察组。结论盐酸氨溴索联合NCPAP治疗新生儿呼吸窘迫综合征疗效肯定,肺部感染等并发症少,氧疗时间短,明显优于常规机械通气。

Objective To evaluate the therapeutic effect of nasal continuous positive pressure ventilation (NCPAP) combined with ambroxol hydrochloride in the treatment of neonatal respiratory distress syndrome (NRDS) and to compare with conventional mechanical ventilation. Methods 52 cases of NRDS children were observed and randomly divided into two groups, the treatment group and the observation group of 26 cases, the treatment group ambroxol hydrochloride combined with NCPAP treatment, the observation group routine use of mechanical ventilation. Control indicators: clinical symptoms and signs, blood gas analysis, oxygen therapy time, complications. Results At 24 and 48 hours after treatment, the clinical symptoms, signs and blood gas analysis were significantly improved in both groups with no significant difference. However, complications such as pulmonary infection and oxygen therapy time in the treatment group were all less than those in the observation group. Conclusions Ambroxol hydrochloride combined with NCPAP is effective in treating neonatal respiratory distress syndrome with less complications such as pulmonary infection and shorter oxygen therapy time, which is obviously superior to conventional mechanical ventilation.