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目的:建立犬冠状动脉脂肪栓塞动物模型,为介入性无复流发生过程中脂肪栓塞的作用提供理论依据。方法:杂种犬20只,施行左室造影及冠状动脉造影,记录血流动力学参数,脂肪栓子注入后,造成犬优势动脉无复流,观察造影结果。同步监测体表心电图,并监测其后组织学及超微结构的改变。结果:建模中共有17只犬成活,其中15只犬达到冠状动脉造影无复流动物模型的标准,即(TIMI)血流≤Ⅱ级,校正的TIMI血流记帧法(CTFC)≥36.2帧,建模成功率75%。慢/无血流模型建立成功后,心率增快,血压下降,左室收缩末压显著降低(P<0.05)。实验过程中,体表心电图出现急性心肌损伤及再灌注的心电图衍变规律。结论:选择性冠状动脉内注入脂肪栓子建立的慢/无血流犬模型是成功的。
Objective: To establish an animal model of canine coronary artery fat embolism to provide theoretical basis for the role of fat embolism in the process of interventional no reflow. Methods: 20 hybrid dogs were subjected to left ventricular angiography and coronary angiography. The hemodynamic parameters were recorded. After the fat embolus was infused, no predominant arteries were found in the canines, and the imaging results were observed. Simultaneous monitoring of body surface ECG and monitoring of subsequent histological and ultrastructural changes. RESULTS: A total of 17 dogs survived in modeling, of which 15 dogs achieved the standard of no-reflow coronary artery angiography (TIMI) flow ≤ Grade II, corrected TIMI flow rate frame method (CTFC) ≥36.2 Frame, modeling success rate of 75%. After successful establishment of the slow / no-flow model, heart rate increased, blood pressure decreased and left ventricular end-systolic pressure decreased significantly (P <0.05). During the experiment, ECG changes of acute myocardial injury and reperfusion occurred on the body surface electrocardiogram. CONCLUSIONS: A slow / non-blood flow canine model established by selective coronary stenting with fat emboli was successful.