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在当今癌基因研究中,研究癌组织中有关癌基因产物已成为探讨肿瘤发病机制以及把癌基因的激活与肿瘤发展的临床表现联系起来的一个重需的不可缺少的研究手段。 血小板来源的生长因子(PDGF)是血清中刺激细胞生长的主要致分裂原,对间叶组织来源的成纤维细胞等有专一的刺激细胞生长作用。近年发现不少人的肿瘤细胞系都分泌PDGF样蛋白。PDGF基因的过高表达被认为与细胞的增生和恶性转化有密切关
In today’s oncogene research, research on oncogene products in cancerous tissues has become an indispensable and indispensable research tool in exploring the pathogenesis of tumors and linking the activation of oncogenes to the clinical manifestations of tumor progression. Platelet-derived growth factor (PDGF) is the major mitogen that stimulates cell growth in serum and specifically stimulates cell growth on mesenchymal cells derived from mesenchymal cells. In recent years, many human tumor cell lines have been found to secrete PDGF-like protein. Over-expression of PDGF gene is thought to be closely related to cell proliferation and malignant transformation