Effect of beta-tricalcium phosphate/poly-l-lactide composites on radial bone defects of rabbit

• 作 者: Zhao-Jin Zhu Hao Shen Yong-Ping Wang Yao Jiang Xian-Long Zhang Guang-Yin Yuan
• 机 构: Medical Board of Graduate School of Suzhou University, Suzhou 215000, Jiangsu, China“,”0rthopedic Su
• 出 处: 亚太热带医药杂志（英文版）
• 发表日期: 2013年9期
• 关键词: β-TCP/PLLA Large segment of simulated-bioactive bone substitute Bone defect

Objective:To explore the effect ofβ-TCP/PLLA scaffold in repairing rabbit radial bone defects. Methods: Thirty New Zealand rabbits were divided intoβ-TCP/PLLA group (group A), pure PLLA group (group B) and contrast group (group C) randomly. The rabbits were sacrificed respectively after 4, 8, 12, 24 weeks and the X-ray film was performed at the same time to evaluate the repair effect in different groups. Results:X-ray film showed there was uneven low density bone callus development in defect region after 4 weeks in group A. The defect region was filled with neonate osseous tissue completely during 12-24 weeks. X-ray score revealed that repair of bone defect results significantly better than group B and group C. Conclusions: Theβ-TCP/PLLA composite is capable of repairing radial bone bone defects.β-TCP/PLLA scaffold is significant because of rapid degradation ability, good histocompatibility and osteogenic action.