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目的农药探讨血液灌流联合CRRT治疗农药中毒引起的急性肾损伤的临床疗效。方法选取我院收治的90例中毒引起的急性肾损伤患者的临床资料,病例收治时间在2012年3月至2015年6月,将患者随机分为两组,每组各有病例45例。对照组采用血液灌流联合血液透析治疗,观察组给予血液灌流联合CRRT治疗,比较两组患者的治疗效果、住院时间、肾功能恢复时间、生化指标。结果 1观察组治疗总有效率为95.56%,对照组治疗总有效率为77.78%,差异有统计学意义(P<0.05)。2观察组的住院时间、肾功能恢复时间短于对照组,差异有统计学意义(P<0.05)。3观察组治疗后的生化指标(CHE、SGPT、LDH、CK、DB、Cr、BUN)与对照组相比有统计学意义(P<0.05)。结论因农药中毒所致的急性肾功能衰竭患者经血液灌流联合CRRT治疗,可有效改善患者病情,缩短肾功能恢复时间与住院时间,值得临床推广应用。
Objective To investigate the clinical effect of hemoperfusion combined with CRRT on acute kidney injury caused by pesticide poisoning. Methods The clinical data of 90 patients with acute renal injury caused by poisoning were selected from March 2012 to June 2015 in our hospital. The patients were randomly divided into two groups, 45 patients in each group. The control group was treated with hemoperfusion and hemodialysis. The observation group was given hemoperfusion combined with CRRT. The therapeutic effect, hospitalization time, recovery time of renal function and biochemical indexes were compared between the two groups. Results 1 The total effective rate of the observation group was 95.56%, while the total effective rate of the control group was 77.78%, the difference was statistically significant (P <0.05). 2 observation group hospitalization time, renal function recovery time is shorter than the control group, the difference was statistically significant (P <0.05). The biochemical indexes (CHE, SGPT, LDH, CK, DB, Cr, BUN) in the observation group after treatment were significantly higher than those in the control group (P <0.05). Conclusions The treatment of acute renal failure caused by pesticide poisoning by hemoperfusion combined with CRRT can effectively improve the condition of patients and shorten the recovery time of renal function and hospital stay, which deserves clinical application.