Deletion of Gpr128 results in weight loss and increased intestinal contraction frequency

• 作 者: Ying-Yin Ni Yan Chen Shun-Yuan
• 机 构: DepartmentofMedicalGenetics,ResearchCentreforExperimentalMedicine,DepartmentofPhysiology,ShanghaiRes
• 出 处: 世界胃肠病学杂志：英文版（电子版）
• 发表日期: 2014年2期
• 关键词: G-protein-coupled RECEPTORS Gpr128 KNOCKOUT mouse G-protein-coupled receptors G
• 基金项目: Shanghai Municipal Health Bureau Foundation,No.2010037,the National Natural Science Foundation of China,Nos.30900156,81071444 and 31000986

AIM:To generate a Gpr128 gene knockout mouse model and to investigate its phenotypes and the biological function of the Gpr128 gene.METHODS:Bacterial artificial chromosome-retrieval methods were used for constructing the targeting vector.Using homologous