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目的探讨低分子肝素钙治疗不稳定性心绞痛的疗效。方法将50例不稳定性心绞痛患者随机分成治疗组和对照组,对照组采用口服肠溶阿司匹林0.1g、消心痛10mg,并用5%葡萄糖液加硝酸甘油5～10mg静脉滴注;治疗组在对照组常规药物治疗基础上使用低分子肝素钙5 000U皮下注射,每12h1次,连用7d。观察两组心绞痛发作及心电图变化,1周后评定疗效。结果治疗组对不稳定性心绞痛的临床疗效达92%,与常规对照组68%比较,差异有统计学意义(P<0.05);治疗组心电图改善84%,与对照组60%比较,差异亦有统计学意义(P<0.05)。结论低分子肝素钙可使不稳定性心绞痛患者临床症状及心电图有明显改善,且使用方便,是一种疗效显著、安全、值得临床推广使用的药物。
Objective To investigate the effect of low molecular weight heparin on unstable angina pectoris. Methods Fifty patients with unstable angina were randomly divided into treatment group and control group. In the control group, oral enteric-coated aspirin 0.1g and ecstasy 10mg were given intravenously and treated with 5% dextrose plus nitroglycerin 5-10mg intravenously. In the control group, Group conventional drug therapy based on the use of low molecular weight heparin 5000U subcutaneous injection, every 12h1 times, once every 7d. Two groups of angina pectoris and electrocardiogram changes were observed. The curative effect was evaluated after one week. Results The clinical efficacy of the treatment group on unstable angina pectoris reached 92%, which was significantly different from that of the conventional control group (P <0.05); the electrocardiogram of the treatment group improved 84%, compared with 60% of the control group There was statistical significance (P <0.05). Conclusion Low molecular weight heparin can significantly improve the clinical symptoms and electrocardiogram in patients with unstable angina and is easy to use. It is a kind of effective and safe drug worthy of clinical application.