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目的探讨血清sFas、sFasL和sIL-2R水平与扩张型心肌病(DCM)之间的关系。方法应用酶联免疫吸附双抗体夹心(ELISA)方法,测定30例DCM患者(DCM组)和22例对照组患者的血清可溶性Fas(sFas)、可溶性Fas配体(sFasL)和可溶性白细胞介素2受体(sIL-2R)水平。结果血清sFas和血清sIL-2R平均水平,DCM组[(1718.50±119.57)ng/L、(855.00±78.03)ng/L]明显高于对照组[(1259.74±143.22)ng/L、(632.64±94.82)ng/L],有显著性差异。在DCM组中,血清sFas和血清sIL-2R平均水平随其心功能分级(NYHA分级I～IV)升高而增高。DCM组sFasL平均水平[(165.31±138.99)ng/L]与对照组[(169.85±149.63)ng/L]比较无显著性差异。DCM组血清sFas水平与sIL-2R水平存在显著正相关。结论DCM患者血清sFas、sIL-2R水平明显升高,提示其与DCM有关。血清sFas可能通过维持自身免疫炎性反应促进心肌细胞凋亡而导致DCM的发生发展。
Objective To investigate the relationship between serum sFas, sFasL and sIL-2R levels and dilated cardiomyopathy (DCM). Methods Serum levels of soluble Fas (sFas), soluble Fas ligand (sFasL) and soluble interleukin 2 (IL-2) in 30 patients with DCM and 22 controls were measured by enzyme linked immunosorbent assay (ELISA) Receptor (sIL-2R) levels. Results Compared with the control group [(1259.74 ± 143.22) ng / L and (632.64 ±)], the mean levels of serum sFas and serum sIL-2R in DCM group [(1718.50 ± 119.57) ng / L and (855.00 ± 78.03) ng / 94.82) ng / L], there is a significant difference. In DCM group, the average levels of serum sFas and serum sIL-2R increased with their cardiac function classification (NYHA classification I ~ IV). The mean level of sFasL in DCM group [(165.31 ± 138.99) ng / L] was not significantly different from that in control group [(169.85 ± 149.63) ng / L]. There was a significant positive correlation between serum sFas level and sIL-2R level in DCM group. Conclusion Serum levels of sFas and sIL-2R were significantly increased in patients with DCM, suggesting that it is associated with DCM. Serum sFas may promote the development of DCM by maintaining autoimmune inflammatory response and promote cardiomyocyte apoptosis.