论文部分内容阅读
Objective.-To classify the headache syndromes under treatment with calcineuri n inhibitors and to investigate whether the latter influence the nitric oxide pr oduction of human brain microvascular cells (HBMEC). Background. Single cases of cyclosporine-induced headaches have been reported. Since calc ineurin inhibitors are known to influence the renal metabolism of NO, a key mole cule in tension-type headache and migraine, we were interested whether calcineu rin inhibitors might change NO metabolism in HBMEC as well. Design and Methods.H eadache symptoms of 74 patients receiving cyclosporine and/or tacrolimus for org an transplantation were retrospectively assessed. Furthermore, the effect of cyc losporine and tacrolimus on nitric oxide production in human brain microvascular endothelial cells was investigated after incubation. Results.Only 18 of the 74 patients reported no headache 1-36 months after liver, lung, or bone-marrow tr ansplantation,28 reported a new headache, and 17 an increase in the frequency or intensity of a pre-existing headache. The headache was generally classified as migraine without aura (IHS 1.1)-or migraine-like headache (IHS 1.6). Furtherm ore, we found significantly increased NO production after co-incubation of calc ineurin inhibitors with human brain microvascular endothelial cells. Conclusion. The pathophysiological mechanism of these headaches may be connected with an end othelial dysfunction in terms of increased production of NO.
Objectives-To classify the headache syndromes under treatment with calcineurin inhibitors and to investigate whether the latter influence the nitric oxide production of human brain microvascular cells (HBMEC). Background. Single cases of cyclosporine-induced headaches have been reported. ineurin inhibitors are known to influence the renal metabolism of NO, a key mole cule in tension-type headache and migraine, we were interested whether calcineurin inhibitors might change NO metabolism in HBMEC as well. Design and Methods. Hepatache symptoms of 74 patients receiving cyclosporine and / or tacrolimus for org an transplantation were retrospectively assessed. Furthermore, the effect of cyc losporine and tacrolimus on nitric oxide production in human brain microvascular endothelial cells was investigated after incubation. Results. Ofly 18 of the 74 patients reported no headache 1 -36 months after liver, lung, or bone-marrow tr ansplantation, 28 reported a new headache, and 17 an inc rease in the frequency or intensity of a pre-existing headache. The headache was generally classified as migraine without aura (IHS 1.1) -or migraine-like headache (IHS 1.6). Further m ore, we found significantly increased production after co-incubation of calcineurin inhibitors with human brain microvascular endothelial cells. Conclusion. The pathophysiological mechanism of these headaches may be connected with an endothelial dysfunction in terms of increased production of NO.