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目的:比较黄连胆汁炙前后对干酵母致热大鼠解热作用的差异。方法:雄性SD大鼠,经筛选后随机分为空白对照组、模型对照组、阿司匹林组、生黄连低和高剂量组、胆黄连低和高剂量组、胆汁低和高剂量组。采用干酵母皮下注射方法制备发热模型,空白对照组ig给予生理盐水,阿司匹林组ig给予阿司匹林0.1 g/kg,生黄连和胆汁炙黄连低、高剂量组分别ig给予对应药物0.9、3.6 g/kg,胆汁低、高剂量组分别ig给予对应药物0.4、1.6 g/kg后分别于各个时间点监测直肠温度,比较作用的差异性。HPLC测定黄连胆汁炙前后盐酸小檗碱、盐酸巴马汀、盐酸黄连碱、盐酸表小檗碱的含量变化。结果:胆汁组和生黄连高剂量组具有解热作用,生黄连低剂量组和胆黄连高剂量组未见明显解热作用。胆黄连中盐酸小檗碱、盐酸黄连碱、盐酸巴马汀和盐酸小檗碱的含量均低于生黄连中的含量。结论:生黄连的解热作用强于胆黄连。
OBJECTIVE: To compare the antipyretic effects of Coptis chinensis biloba on the hyperthermic rats induced by dry yeast. Methods: Male Sprague-Dawley rats were randomly divided into blank control group, model control group, aspirin group, low and high dosage group of berberine, low and high dosage of bile-chonglian group, low and high bile group. The model of fever was prepared by subcutaneous injection of dry yeast. The blank control group was given normal saline. The aspirin group was given aspirin 0.1 g / kg, and the crude berberine and bile Sunburn Coptis low and high dose group were given corresponding drugs 0.9, 3.6 g / kg , Low bile, high dose group were given ig corresponding drugs 0.4,1.6 g / kg, respectively, at various time points to monitor the rectal temperature, the role of the difference. Determination of Berberine Hydrochloride, Palmatine Hydrochloride, Coptisine Hydrochloride, Berberine Hydrochloride in Hydrochloric Acid of Coptis Chinensis by. Results: The bile group and Shenghuanglian high-dose group had antipyretic effect, and no obvious antipyretic effect was observed in the low-dose Huanghuanglian group and the high-dose Huanghuanglian group. The contents of berberine hydrochloride, berberine hydrochloride, palmatine hydrochloride and berberine hydrochloride in bile-chuandi were lower than those in berberine. Conclusion: The antipyretic effect of raw berberine is stronger than that of gallbladder.