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目的探讨在2型糖尿病(T2DM)合并非酒精性脂肪性肝病患者中检测空腹血清同型半胱氨酸(tHCY)及血清铁蛋白(SF)的临床意义。方法将195例T2DM患者分为单纯糖尿病组(A组)83例,合并非酒精性脂肪肝组(B组)60例及合并非酒精性脂肪性肝炎组(C组)52例,分别测定身高,体重,抽空腹血检查tHCY、SF、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、糖化血红蛋白(HbA1C)、空腹血糖(FBG)及空腹胰岛素(FINS)等。计算体质指数(BMI)及胰岛素抵抗指数(HOMA-IR)。结果 B组BMI、TG、TC、LDL-C、ALT、AST、GGT、tHCY、SF、FINS、HOMA-IR均明显高于A组(P<0.05),C组均明显高于B组(P<0.05)。而B组HDL-C均明显低于A组(P<0.05),C组均明显低于B组(P<0.05)。3组间HbA1C、FBG及年龄差异无统计学意义。Pearson相关分析结果显示,tHCY与BMI、TG、TC、LDL-C、FINS、HOMA-IR呈显著正相关(P<0.05),与HDL-C呈显著负相关(P<0.05);SF与BMI、TG、TC、LDL-C、FINS、HOMA-IR呈显著正相关(P<0.05),与HDL-C呈显著负相关(P<0.05)。结论 tHCY及SF是T2DM合并非酒精性脂肪性肝病的危险因素,并且与BMI、TG、TC、LDL-C、FINS、HOMA-IR、HDL-C水平具有相关性。
Objective To investigate the clinical significance of detecting fasting serum homocysteine (tHCY) and serum ferritin (SF) in type 2 diabetes mellitus (T2DM) patients with non-alcoholic fatty liver disease. Methods A total of 195 patients with T2DM were divided into three groups: 83 patients with simple diabetes mellitus (A group), 60 patients with non-alcoholic fatty liver disease (Group B) and 52 patients with non-alcoholic steatohepatitis (Group C) , Body weight and fasting blood were tested for tHCY, SF, total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL- (ALT), aspartate aminotransferase (AST), glutamyl transpeptidase (GGT), glycosylated hemoglobin (HbA1C), fasting blood glucose (FBG) and fasting insulin (FINS) and so on. Body mass index (BMI) and insulin resistance index (HOMA-IR) were calculated. Results The BMI, TG, TC, LDL-C, ALT, AST, GGT, tHCY, SF, FINS and HOMA-IR in group B were significantly higher than those in group A (P < <0.05). However, HDL-C in group B was significantly lower than that in group A (P <0.05), and in group C was significantly lower than that in group B (P <0.05). There was no significant difference in HbA1C, FBG and age between the three groups. Pearson correlation analysis showed that there was a significant positive correlation between tHCY and BMI, TG, TC, LDL-C, FINS and HOMA-IR (P <0.05) , TG, TC, LDL-C, FINS and HOMA-IR (P <0.05), but negatively correlated with HDL-C (P <0.05). Conclusions tHCY and SF are risk factors of T2DM with non-alcoholic fatty liver disease, and are correlated with the levels of BMI, TG, TC, LDL-C, FINS, HOMA-IR and HDL-C.