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目的研究白细胞介素-4(interleukin-4,IL-4)基因-590C/T及-34C/T多态性与慢性牙周炎易感性的关系。方法采用病例对照实验设计,采用聚合酶链反应-限制性内切酶片段长度多态性基因分析方法,比较104例慢性牙周炎患者和106例牙周健康者IL-4基因-590位点、-34位点基因型和等位基因分布特点。结果 IL-4基因-590位点C、T等位基因频率及基因型在两组间分布差异无统计学意义(P>0.05),IL-4基因-34位点C、T等位基因频率及基因型在两组间分布差异无统计学意义(P>0.05)。结论 IL-4基因-590、-34位点的多态性与汉族人群慢性牙周炎的易感性无明显相关性。
Objective To investigate the relationship between -590C / T and -34C / T polymorphisms of interleukin-4 (IL-4) gene and susceptibility to chronic periodontitis. Methods A case-control study was designed. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to analyze the polymorphism of IL-4 gene at position -90 in 104 patients with chronic periodontitis and 106 healthy persons with periodontal disease , -34 loci genotype and allele distribution characteristics. Results There was no significant difference in frequencies of C and T alleles between the -590 locus of IL-4 gene and genotypes (P> 0.05). The frequencies of C and T alleles at IL-4 gene -34 loci There was no significant difference in genotype distribution between the two groups (P> 0.05). Conclusion The polymorphism of -590 and -34 loci in IL-4 gene has no significant correlation with susceptibility to chronic periodontitis in Han nationality.