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为了探讨红细胞膜钠－锂逆转换活性（ＳＬＣＡ）与Ⅱ型糖尿病血脂异常之间的关系，采用Ｆｕｊｉｔａ等的方法，测定了８１例Ⅱ型糖尿病患者、４０例正常人的ＳＬＣＡ，并对其血脂水平和胰岛素敏感性指数（ＩＳＩ）进行检测，结果显示Ⅱ型糖尿病患者ＳＬＣＡ（０．３６１±０．１３９ｍｍｏｌ／Ｌ ＲＢＣ／ｈ）明显高于正常对照（０．１９１±０．０８３ｍｍｏｌ／Ｌ·ＲＢＣ／ｈ）（Ｐ＜０．０１）；分别以ＳＬＣＡ和ＩＳＩ为应变量作逐步回归分析，发现ＳＬＣＡ与ＩＳＩ、ＨＤＬ２呈负相关，与ＴＧ呈正相关；ＩＳＩ与ＨＤＬ２正相关，与ＴＧ呈负相关。提示（１）ＳＬＣＡ在Ⅱ型糖尿病升高，（２）ＳＬＣＡ与Ⅱ型糖尿病胰岛素敏感性及其脂代谢异常有关，并可能作为反映Ⅱ型糖尿病机体胰岛素敏感性指标之一。
In order to investigate the relationship between sodium-lithium inverse conversion activity (SLCA) of erythrocytes membrane and dyslipidemia of type 2 diabetes mellitus, SLCA was measured in 81 patients with type 2 diabetes mellitus and 40 normal persons by Fujita et al. (0.361 ± 0.139mmol / L RBC / h) were significantly higher in patients with type 2 diabetes than those in normal controls (0.191 ± 0.083mmol / L · RBC /h)(P<0.01); SLCA and ISI as the dependent variable for stepwise regression analysis showed that SLCA and ISI, HDL2 was negatively correlated with TG was positively correlated; ISI was positively correlated with HDL2 and negatively correlated with TG . It suggests that (1) SLCA is elevated in type 2 diabetes mellitus, (2) SLCA is associated with insulin sensitivity and dyslipidemia in type 2 diabetes and may be one of the indicators of insulin sensitivity in type 2 diabetes mellitus.