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目的分析不同子宫内膜疾病中瘦素含量与血管内皮生长因子(VEGF)阳性表达率间的差异,并探讨瘦素含量与VEGF阳性表达率在不同子宫内膜疾病中的意义。方法 30例无子宫内膜疾病女性、50例子宫内膜增生患者及30例子宫内膜癌患者作为观察对象,分别设为A组,B组,C组。对比三组瘦素含量与VEGF阳性表达率间的差异。结果三组间瘦素含量以C组(823.56±125.35)pg/ml含量最高,A组含量最低,两两比较差异有统计学意义(P<0.05);同时三组间VEGF阳性表达率同样以C组阳性表达率70.00%为最高,A组阳性表达率最低,两两比较差异有统计学意义(P<0.05)。结论不同子宫内膜疾病中瘦素含量与VEGF阳性表达率存在显著的差异,临床可将瘦素含量与VEGF阳性表达率作为鉴别不同子宫内膜疾病的指标。
Objective To analyze the difference between the expression of leptin and VEGF in different endometrial diseases and to explore the significance of leptin content and VEGF expression in different endometrial diseases. Methods Thirty patients without endometrial disease, 50 patients with endometrial hyperplasia and 30 patients with endometrial cancer were divided into group A, group B and group C, respectively. The differences between the three groups in leptin content and VEGF positive expression rate were compared. Results The leptin content in the three groups was the highest in group C (823.56 ± 125.35) pg / ml, the lowest in group A, and the difference was statistically significant (P <0.05). The positive rate of VEGF in the three groups The positive rate of C group was 70.00%, the lowest was in group A, and the difference was statistically significant (P <0.05). Conclusions There is a significant difference between leptin content and VEGF expression in different endometrial diseases. Leptin content and VEGF positive rate can be used clinically to identify different endometrial diseases.