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目的:分析老年2型糖尿病患者骨骼肌质量和力量水平，探讨慢性炎症及氧化应激水平对其影响。方法:横断面病例对照研究，入选京西医院120例60岁及以上老年2型糖尿病(糖尿病组)患者和126例老年非糖尿病(非糖尿病组)患者，分别测定其骨骼肌质量、力量及血清慢性炎症因子白细胞介素6(IL-6)、肿瘤坏死因子-α(TNF-α)及氧化应激产物8-羟基脱氧鸟苷(8-OHdG)水平，分析其对老年2型糖尿病患者骨骼肌量和肌力的影响。结果:糖尿病组患者握力低于非糖尿病组，(25.03±7.85)kg比(29.52±7.73)kg(n P0.05)。糖尿病组患者血清中8-OHdG水平(3.08±0.26)ng/L高于非糖尿病组(2.59±0.16)ng/L(n P<0.01)。相关性和回归分析结果显示，8-OHdG为老年2型糖尿病患者肌力的影响因素(n R2＝0.457)，身高、体重可能为老年2型糖尿病患者骨骼肌质量的影响因素(n R2＝0.822)。n 结论:老年2型糖尿病患者骨骼肌衰退，其可能与糖尿病患者体内氧化应激水平的升高有关，为老年糖尿病患者肌少症的干预提供依据。“,”Objective:To analyze the mean levels of skeletal muscle mass and strength in elderly patients with type 2 diabetes mellitus(T2DM), and to investigate the effects of chronic inflammatory factors and oxidative stress on them.Methods:A cross-sectional study was conducted on 120 patients with T2DM aged over 60 years and 126 elderly patients without diabetes(the control group). Skeletal muscle mass, strength and serum levels of chronic inflammatory factors interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)and 8-hydroxy-2′-deoxyguanosine(8-OHdG)were determined, and their effects on skeletal muscle mass and strength in elderly patients with T2DM were analyzed.Results:Compared with the control group, grip strength decreased in elderly patients with T2DM(25.03±7.85)kg n vs.(29.52±7.73)kg(n P0.05). Serum levels of 8-OHdG were higher in elderly patients with T2DM than in the control group(3.08±0.26)ng/Ln vs.(2.59±0.16)ng/L(n P<0.01). Correlation and regression analysis results showed that 8-OHdG was an influencing factor for muscle strength in elderly patients with T2DM(n R2=0.457)and that height and weight could be influencing factors for skeletal muscle mass in elderly patients with T2DM(n R2=0.822).n Conclusions:Skeletal muscle mass and strength decline in elderly T2DM patients, probably as a result of increased levels of oxidative stress.These findings may serve as evidence for sarcopenia intervention in elderly T2DM patients.