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糖尿病患者,随着病程的发展,其病变可累及肾血管、肾小球、肾小管和间质,导致糖尿病性肾脏病变。患者首先出现肾小球滤过率的增加,其次出现蛋白尿。肾病综合征,最后发生肾功能衰竭。糖尿病患者一旦出现大量蛋白尿,则多数有严重的肾组织损害。早期因肾小球滤过屏障受损较轻,只有分子量较小的白蛋白漏出,此时为选择性蛋白尿。呈后期,则大分子的IgG亦能漏出,为混合性蛋白尿。尿中排出β_2—微球蛋白(β_2—mG),提示肾小方功能的损害。临床上测定尿β_2—mG值能较早期发现肾小管重吸收和排泌功能改变。早已
Diabetic patients, with the progression of the disease, the lesion can affect renal vessels, glomeruli, tubules and interstitial, leading to diabetic nephropathy. Patients first showed an increase in glomerular filtration rate, followed by proteinuria. Nephrotic syndrome, the final occurrence of renal failure. Diabetic patients in the event of a large number of proteinuria, the majority of severe renal tissue damage. Early damage due to glomerular filtration barrier lighter, only the smaller molecular weight albumin leakage, this time for the selective proteinuria. Was late, then the macromolecules can also leak IgG, mixed proteinuria. Urinary excretion of β_2-microglobulin (β_2-mG), suggesting that renal function impairment. Clinical determination of urinary β_2-mG values can be found earlier renal tubular reabsorption and excretion of functional changes. Already