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目的观察鼻咽癌受损颅神经功能恢复与病程的关系。方法 37例鼻咽癌患者共有 6 8条受损颅神经 ,均接受 6 MV - X线放疗 ,鼻咽及颅底 DT70 - 84 Gy,中位 DT74 Gy。结果 6 8条受损颅神经功能完全缓解 5 1.5 % (35 / 6 8) ,颅神经受损 <4个月的患者放疗后功能完全缓解 82 .5 % (33/ 4 0 ) ,而 >4个月完全缓解 7.14 % (2 / 2 8) ,两者比较差异有显著性 (P<0 .0 1)。结论鼻咽癌受损颅神经放疗后其功能大部分可以恢复 ,颅神经受损 <4个月其功能恢复的可能性大 ,而 >4个月其功能恢复的可能性较小。
Objective To observe the relationship between the functional recovery of cranial nerves with nasopharyngeal carcinoma and the course of disease. Methods A total of 68 craniocerebral lesions of 37 patients with nasopharyngeal carcinoma were treated with 6 MV - X radiotherapy, DT70 - 84 Gy in the nasopharynx and skull base, and median DT74 Gy. Results In 6 of 8 cases, the complete functional recovery of injured cranial nerves was 51.5% (35/68). The patients with cranial nerve injury <4 months had complete remission of 82.5% (33/40) after radiotherapy and> 4 Month completely relieved 7.14% (2/2 8), the difference between the two was significant (P <0.01). Conclusion The function of cranial nerve after nasopharyngeal injury is mostly recovered after radiotherapy. The cranial nerve impaired is less likely to recover after less than 4 months. However, the functional recovery is less likely after 4 months.