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【目的】了解深圳市宝安区沙井镇学龄前儿童乙型肝炎病毒的感染及免疫状况。【方法】抽取1~6岁入托(入园)前的学龄前儿童静脉血3 mL,采用ELISA法检测乙型肝炎病毒五项血清标志物,包括HBsAg、抗-HBs、HbeAg、抗-HBe和抗-HBc。【结果】4 901例规范接种过乙肝疫苗的学龄前儿童HbsAg携带率为1.43%;抗-Hbs阳性率为53.54%,其中的23.78%为弱阳性;五项血清标志物均为阴性的占总被检人数的45.03%。【结论】婴幼儿在完成乙肝全程初次免疫后,应注意动态观察抗-HBs水平,及时补种乙肝疫苗,巩固免疫效果。
【Objective】 To understand the infection and immune status of hepatitis B virus among preschool children in Shajing Town, Bao’an District, Shenzhen City. 【Method】 Three mL of venous blood of pre-school children aged 1 ~ 6 years old were enrolled in this study. Five serological markers of hepatitis B virus including HBsAg, anti-HBs, HbeAg, anti-HBe, Anti-HBc. 【Results】 The 4 901 HbsAg carriers of pre-school children who received hepatitis B vaccine were 1.43%, the positive rate of anti-HBs was 53.54%, of which 23.78% were weakly positive. The five serum markers were all negative The number of seized 45.03%. 【Conclusion】 Infants and young children should pay attention to the dynamic observation of the anti-HBs level after completing the primary immunization of hepatitis B patients and promptly replant the hepatitis B vaccine to consolidate the immune effect.