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目的比较国内内膜剥脱术(CEA)与支架成形术(CAS)治疗颈动脉狭窄的临床效果。方法检索2006年1月-2017年1月国内公开发表的CAS与CEA治疗颈动脉狭窄的随机对照试验(RCT)文献,按照标准进行文献筛选,获取相关临床观察指标并进行Meta分析。结果按照筛选标准,共有5篇RCT共计491例颈动脉狭窄患者纳入分析。CAS组与CEA组患者存在危险因素等特征均衡。两组发生死亡、脑梗死、颈动脉急性闭塞、高灌注综合征、心肌梗死、重度再狭窄的差异均无统计学意义(P>0.05)。结论在相同危险因素下,CAS组与CEA组发生死亡、脑梗死、颈动脉急性闭塞、高灌注综合征、心肌梗死、重度再狭窄几率相当。
Objective To compare the clinical effects of domestic endarterectomy (CEA) and stenting (CAS) in the treatment of carotid artery stenosis. METHODS: A randomized controlled trial (RCT) of CAS and CEA for the treatment of carotid stenosis was published from January 2006 to January 2017 in China. The literatures were screened according to the standard and relevant clinical observation indexes were obtained and analyzed by meta-analysis. Results According to the screening criteria, a total of 5 RCTs were included in 491 cases of carotid stenosis. Patients in the CAS and CEA groups had equal risk characteristics. There were no significant differences in death, cerebral infarction, acute carotid occlusion, hyperperfusion syndrome, myocardial infarction and severe restenosis between the two groups (P> 0.05). Conclusions Under the same risk factors, death occurred in CAS and CEA groups. The incidence of cerebral infarction, acute carotid artery occlusion, hyperperfusion syndrome, myocardial infarction and severe restenosis was similar.