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目的:探讨重症肌无力(MG)患儿在使用糖皮质激素(GC)治疗前、后血清皮质醇的变化。方法:选取新发MG患儿43例和健康儿童微量元素抽查群体19例,取静脉血上清液用化学发光法测定其血清皮质醇水平,MG患儿抽血时间为治疗前及治疗后2个月时。结果:新发MG患儿治疗前血清皮质醇水平明显高于正常对照组(P<0.05)和GC治疗后(P<0.01),而正常对照组血清皮质醇水平与GC治疗后患儿的血清皮质醇水平比较差异无统计学意义(P>0.05)。结论:外源性GC对改善MG患儿由于异常应激状态及免疫功能紊乱等导致体内血清皮质醇升高有较好的纠正作用。
Objective: To investigate the changes of serum cortisol in children with myasthenia gravis (MG) before and after treatment with glucocorticoid (GC). Methods: Forty-three patients with newly diagnosed MG and 19 children with healthy children were enrolled in this study. Serum cortisol level was determined by chemiluminescence method in venous supernatant. The time of taking blood in MG patients was before and after treatment Months Results: Serum cortisol level in newly diagnosed MG patients was significantly higher than that in normal control group (P <0.05) and GC treatment (P <0.01), while serum cortisol level in normal control group was significantly higher than that in normal control group Cortisol levels were no significant difference (P> 0.05). Conclusion: Exogenous GC can improve the level of serum cortisol in children with MG due to abnormal stress and immune dysfunction.