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目的研究强效促性腺激素释放激素（ｇｏｎａｄｏｔｒｏｐｉｎ－ｒｅｌｅａｓｉｎｇｈｏｒｍｏｎｅ，ＧｎＲＨ）激动剂那法瑞林（ｎａｆａｒｅｌｉｎ，Ｎａｆ）对兔异位子宫内膜的抑制作用。方法以手术方法制备兔异位子宫内膜模型后，将动物分为对照组、Ｎａｆ（１，３，１０μｇ·ｋｇ－１·ｄ－１各１组，ｓｃ）治疗组，丹那唑（ｄａｎａｚｏｌ，Ｄａｎ，８０ｍｇ·ｋｇ－１·ｄ－１，ｉｇ）治疗组以及手术切除双侧卵巢组（ｂｉｌａｔ－ｅｒａｌｏｖａｒｉｅｃｔｏｍｙ，ＯＶＸ）。结果６ｗｋ后发现，经Ｎａｆ治疗的动物其异位内膜的体积明显减小，其中３和１０μｇ·ｋｇ－１·ｄ－１剂量组的疗效与ＯＶＸ组相似。Ｄａｎ尽管也能引起异位内膜萎缩，但其疗效较Ｎａｆ１０μｇ·ｋｇ－１·ｄ－１和ＯＶＸ有显著差别。另外，Ｎａｆ治疗组动物的血清雌二醇（ｅｓｔｒａｄｉｏｌ，Ｅ２）水平也明显下降。结论Ｎａｆ可明显抑制兔异位子宫内膜的生长，该作用与兔血清内Ｅ２水平下降有关。
Objective To study the inhibitory effect of nafarelin (Naf), a gonadotropin-releasing hormone (GnRH) agonist, on ectopic endometrium of rabbits. Methods Rabbits were divided into control group, Naf group (1, 3, 10μg · kg-1 · d-1 sc each group), danazol Dan, 80 mg · kg-1 · d-1, ig), and bilat-eralovariectomy (OVX). Results After 6 weeks, the volume of ectopic endometrium in Naf-treated animals was significantly reduced, and the effects of 3 and 10 μg · kg-1 · d-1 dose groups were similar to those in OVX group. Although Dan can cause ectopic endometrial atrophy, its efficacy is significantly different from that of Naf10μg · kg-1 · d-1 and OVX. In addition, the serum estradiol (E2) levels in the Naf-treated animals also decreased significantly. Conclusion Naf can significantly inhibit the growth of ectopic endometrium in rabbits, which is related to the decrease of E2 level in rabbit serum.