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目的探讨影响新生儿缺氧缺血性脑病预后的高危因素,以期及早给予正规治疗以减轻或防止后遗症的发生。方法回顾132例新生儿缺氧缺血性脑病患儿的临床资料及随访发育商变化,对影响其预后的高危因素及干预措施进行分析。结果轻、中、重度缺氧缺血性脑病预后不良发生率分别为6.7%、13.5%、24.6%。48小时内入院者轻、中、重度缺氧缺血性脑病预后不良发生率分别为0%、4.8%、15.6%,超过48小时入院者轻、中、重度缺氧缺血性脑病预后不良发生率分别为10%、18.8%、34.4%。新生儿期后治疗与否,中度缺氧缺血性脑病预后不良率分别为9.5%和16.1%,重度缺氧缺血性脑病预后不良率分别为15%和40%。结论新生儿缺氧缺血性脑病的临床分度,产科儿科合作程度、家长对疾病认知程度及家庭经济条件、是否能早期正规及序贯治疗等是影响新生儿缺氧缺血性脑病患儿预后的高危因素,早期干预可改善预后。
Objective To investigate the risk factors of neonatal hypoxic-ischemic encephalopathy prognosis, with a view to regular treatment to reduce or prevent the occurrence of sequelae. Methods The clinical data of 132 neonates with hypoxic-ischemic encephalopathy were retrospectively analyzed and the changes of their follow-up and development were retrospectively analyzed. The risk factors influencing their prognosis and the intervention measures were analyzed. Results The poor prognosis of mild, moderate and severe hypoxic-ischemic encephalopathy were 6.7%, 13.5% and 24.6% respectively. The poor prognosis of mild, moderate and severe hypoxic-ischemic encephalopathy in admission within 48 hours were 0%, 4.8% and 15.6%, respectively. Patients with mild, moderate and severe hypoxic-ischemic encephalopathy had poor prognosis after admission for more than 48 hours Rates were 10%, 18.8%, 34.4% respectively. After neonatal treatment or not, the rate of poor prognosis of moderate hypoxic ischemic encephalopathy was 9.5% and 16.1%, respectively, and the rate of poor prognosis of severe hypoxic-ischemic encephalopathy was 15% and 40% respectively. Conclusion neonatal hypoxic-ischemic encephalopathy clinical index, degree of cooperation of obstetrics and gynecology, parental awareness of the disease and family economic conditions, whether the early formal and sequential treatment are neonatal hypoxic-ischemic encephalopathy Prognosis of children with risk factors, early intervention can improve the prognosis.