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目的探讨香菇多糖联合化疗治疗晚期胃癌的治疗效果。方法60例晚期胃癌患者随机分为两组,A组30例予香菇多糖加TPF方案(紫杉醇+顺铂+5-氟尿嘧啶)化疗作为试验组,B组30例除不用香菇多糖外其他治疗相同作为对照组。8周后观察近期疗效、生活质量变化及毒副反应情况。结果近期疗效A组高于B组,分别为73%和47%,有显著性差异(P<0.05)。Karnofsky评分评定为上升的比率A组高于B组,分别为47%(14/30)和27%(8/30),有显著性差异(P<0.05)。下降的比率A组低于B组,分别为17%(5/30)、40%(12/30),有显著性差异(P<0.05)。B组恶心、呕吐较A组严重,差异有显著性意义;骨髓抑制(白细胞减少)两组无明显差异。结论香菇多糖联合化疗较单纯化疗治疗晚期胃癌能增加疗效,减少化疗毒性反应,并改善生活质量。
Objective To investigate the efficacy of lentinan in combination with chemotherapy in the treatment of advanced gastric cancer. Methods Sixty patients with advanced gastric cancer were randomly divided into two groups. 30 patients in group A received lentinan plus TPF (paclitaxel + cisplatin +5-fluorouracil) chemotherapy as the experimental group. 30 patients in group B received the same treatment except that without lentinan. Control group. After 8 weeks, the short-term efficacy, quality of life, and adverse reactions were observed. Results The short-term efficacy of group A was higher than that of group B (73% and 47%, respectively), with significant difference (P<0.05). The rate of increase in Karnofsky score was higher in group A than in group B, which was 47% (14/30) and 27% (8/30) respectively, with a significant difference (P<0.05). The rate of decline was lower in group A than in group B, which was 17% (5/30) and 40% (12/30), respectively, with a significant difference (P<0.05). Nausea and vomiting were more severe in group B than in group A, with significant differences. There was no significant difference in myelosuppression (leucopenia) between the two groups. Conclusion Compared with chemotherapy alone, lentinan combined with chemotherapy can increase the efficacy, reduce the toxicity of chemotherapy, and improve the quality of life.