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纯种小白鼠１１５只，随机分为对照组（ｎ＝２０），致伤组（ｎ＝３５），ＮＡＣ组（ｎ＝２０）和精氨酸组（ｎ＝２０）及混和组（ｎ＝２０），致伤组经尾静脉注射油酸０．１５ｍｌ／ｋｇ体重，ＮＡＣ组同时注射ＮＡＣ，精氨酸组注射Ｌ－精氨酸，混合组两药同时注射，结果表明，致伤组２４ｈ死亡率为１４％，各治疗组死亡率为零，肺湿重／体重显著小于致伤组（ｐ＜０．０５）肺组织匀浆中ＴＸＢ２，６－ｋｅｔｏ－ＰＧＦ１α和ＭＤＡ显著低于致伤组（Ｐ＜０．０５）；病理组织学显示各治疗组肺损伤明显减轻，表明ＮＡＣ和精氨酸对油酸引起的急性肺损伤有良好的防治作用。
A total of 115 purebred mice were randomly divided into control group (n = 20), injury group (n = 35), NAC group (n = 20) and arginine group (n = 20) 20). The wounds were injected with 0.15 ml / kg body weight of oleic acid through the tail vein. NAC group was injected with NAC at the same time and L-arginine group was injected with arginine group. The two groups were injected simultaneously. The results showed that 24h Mortality was 14%, mortality in each treatment group was zero, and lung wet weight / body weight was significantly less than that in the injury group (p <0.05). The levels of TXB2, 6-keto-PGF1α and MDA in the lung homogenate were significantly lower than those in the injury group (P <0.05). Histopathology showed that lung injury in each treatment group was significantly reduced, indicating that NAC and arginine have a good preventive and therapeutic effect on oleic acid-induced acute lung injury.