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精氨酸加压素（ＡＶＰ）是脑内重要的神经递质，本研究采用４血管关闭的方法，制造Ｗｉｓｔａｒ大鼠全脑反复缺血再灌流长期生存动物模型，然后利用放免方法测定了缺血后存活不同时间大鼠额叶、颞叶、海马、丘脑、纹状体、脑干６个脑区的ＡＶＰ含量。发现缺血即刻各脑区ＡＶＰ无显著变化（Ｐ＞０．０５），缺血后１５天显著下降（Ｐ＜０．０１），３０天时继续下降（Ｐ＜０．０１），６０天时变化方趋稳定，９０天和１８０天时和对照组比较仍有显著差异（Ｐ＜０．０１）。结果提示ＡＶＰ下降与脑对缺血选择易损伤性有关，ＡＶＰ参与了脑缺血病理生理的全过程。
Arginine vasopressin (AVP) is an important intracerebral neurotransmitter. In this study, a long-term survival animal model of Wistar rats with global cerebral ischemia-reperfusion was established by a method of 4-vessel occlusion, and then radioimmunoassay AVP content in frontal lobe, temporal lobe, hippocampus, thalamus, striatum and brainstem of 6 rats in blood survived at different time points. It was found that there was no significant change in AVP in all brain regions immediately after ischemia (P <0.05), significantly decreased at 15 days after ischemia (P <0.01), and continued to decline at 30 days (P <0.01) Stable, 90 days and 180 days compared with the control group there are still significant differences (P <0.01). The results suggest that the decrease of AVP is related to the vulnerability of brain to ischemic selection. AVP participates in the whole process of pathophysiology of cerebral ischemia.