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目的探讨老年急性心肌梗死(AMI)患者外周血T淋巴细胞亚群水平变化与发病关系。方法采用SAP法分别测定31例老年AMI患者、34例老年对照组(NC)的外周血T淋巴细胞亚群水平。结果AMI组CD3+,CD4+,CD4+/CD8+比值低于NC组(P<0.001),而CD8+则高于NC组(P<0.001),差异均有显著性。结论老年AMI患者存在细胞免疫功能紊乱,可能对老年AMI的形成和发展产生了影响。T淋巴细胞亚群比值变化可作为老年AMI严重程度的监测指标,免疫干预可能成为防治老年AMI的新途径。
Objective To investigate the relationship between the changes of peripheral blood T lymphocyte subsets and the pathogenesis of senile acute myocardial infarction (AMI). Methods The levels of T lymphocyte subsets in 31 elderly patients with AMI and 34 elderly controls (NC) were determined by using the SAP method. Results The ratio of CD3 +, CD4 + and CD4 + / CD8 + in AMI group was significantly lower than that in NC group (P <0.001), and CD8 + was higher than that in NC group (P <0.001). Conclusion The elderly patients with AMI have cellular immune dysfunction, which may have an impact on the formation and development of AMI in the elderly. T lymphocyte subsets ratio changes can be used as a monitoring indicator of the severity of AMI in the elderly, immune intervention may become a new way to prevent and treat AMI in the elderly.