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瘦素(1eptin),又名消脂素,是一种由肥胖基因编码的分泌型蛋白,在代谢平衡中主要通过作用于下丘脑特异性受体调节食物摄入和能量平衡[1],起初认为白色脂肪组织是瘦素的惟一来源,进一步研究表明:瘦素存在于骨骼肌、胎盘、乳腺上皮细胞、肝星状细胞等多组织器官中;而瘦素受体除存在于与能量代谢有关的下丘脑、骨骼肌及脂肪组织外,还广泛存在于全身各个组织。人们开始认识到瘦素除了内分泌系统外还应存在其他的生物学效应。近年来研究发现瘦素及其受体存在于人正常胃黏膜组织中[2],它们与胃的胃疾病密切相关,本文就此方面的研究进展作一综述。
Leptin (1eptin), also known as defatin, is a secreted protein encoded by an obesity gene that regulates food intake and energy balance mainly through hypothalamic-specific receptors in the metabolic balance [1] White adipose tissue is considered as the only source of leptin. Further studies have shown that leptin exists in many tissues and organs such as skeletal muscle, placenta, mammary gland epithelial cells and hepatic stellate cells, while leptin receptor exists in addition to energy metabolism Of the hypothalamus, skeletal muscle and adipose tissue, but also widely exist in various tissues of the body. People began to realize that leptin in addition to the endocrine system should also have other biological effects. In recent years, studies have found that leptin and its receptors exist in human normal gastric mucosa [2], which are closely related to gastric diseases, this article reviews the research progress in this area.