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目的 研究bcl-2蛋白在宫颈癌中的表达。方法 采用免疫组化SP法对 6例慢性宫颈炎组织、8例宫颈上皮内瘤变 (CIN)、2 4例宫颈癌组织、6例湿疣组织进行了bcl-2基因蛋白表达测定。结果 宫颈鳞癌中bcl-2阳性表达 (5 4.17% ) ,显著高于炎症组织 (16 .6 7% )及CIN(2 5 % ) (P <0 .0 1)。bcl-2蛋白表达与宫颈癌组织分化程度呈正相关。结论 bcl -2基因变化在宫颈癌的发生和发展中起重要作用 ,其过度表达多见于宫颈癌早期 ,且提示肿瘤较好的预后。
Objective To study the expression of bcl-2 protein in cervical cancer. Methods The expression of bcl-2 protein in 6 cases of chronic cervicitis, 8 cases of cervical intraepithelial neoplasia (CIN), 24 cases of cervical cancer and 6 cases of condyloma acuminatum was detected by immunohistochemical SP method. Results The positive expression of bcl-2 in cervical squamous cell carcinoma (5 4.17%) was significantly higher than that in inflammatory tissues (16.67%) and CIN (25%) (P <0.01). The expression of bcl-2 protein was positively correlated with the differentiation of cervical cancer. Conclusion The change of bcl -2 gene plays an important role in the occurrence and development of cervical cancer. The overexpression of bcl -2 gene is more common in early stage of cervical cancer and suggests a better prognosis of cervical cancer.