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目的:评估热休克蛋白60(HSP60)和膜粘连蛋白-2(annexin-2)在非小细胞肺癌中的诊断意义。方法:100名诊断肺恶性肿瘤患者分为早期肺癌组和晚期肺癌组,每组中再次分为鳞癌亚组和腺癌亚组。由肿瘤病灶处和对应的正常组织处提取新鲜组织测定蛋白表达水平并进行比较。结果:在进展期肺腺癌组中,将肿瘤组织中HSP60和annexin-2的表达量与正常组织进行对比。HSP60的表达量具有统计学差异(P<0.05)。annexin-2的表达量具有统计学意义(P<0.05)。结论:在早期肺癌的诊断中,HSP60和annexin-2是鳞癌和腺癌的重要标记物。
Objective: To evaluate the diagnostic value of HSP60 and annexin-2 in non-small cell lung cancer. Methods: One hundred patients with diagnosed pulmonary malignant tumor were divided into early lung cancer group and advanced lung cancer group. Each group was subdivided into squamous cell subgroup and adenocarcinoma subgroup again. Fresh tissues were harvested from tumor sites and corresponding normal tissues, and their protein expression levels were measured and compared. Results: In the group of advanced lung adenocarcinoma, the expression levels of HSP60 and annexin-2 in tumor tissues were compared with those in normal tissues. HSP60 expression was statistically significant (P <0.05). The expression of annexin-2 was statistically significant (P <0.05). Conclusion: HSP60 and annexin-2 are important markers in squamous cell carcinoma and adenocarcinoma in the diagnosis of early lung cancer.