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目的：探讨子宫内膜增生过长的发病机理，为临床内分泌治疗提供理论基础。方法：应用免疫组织化学Ｓ－Ｐ法，对手术切除和诊刮的６７例不同时期子宫内膜和不同类型增生过长子宫内膜标本进行ＥＲ、ＰＲ和ＰＣＮＡ含量检测分析。结果：ＥＲ、ＰＲ在正常增生期子宫内膜中的含量显著高于分泌期（Ｐ＜０．０１），在单纯性增生过长和复杂性增生过长子宫内膜中ＥＲ、ＰＲ的含量也有显著差异（Ｐ＜０．０１）。各组增生过长子宫内膜中ＥＲ的含量高于ＰＲ（Ｐ＜０．０１）。ＰＣＮＡ在内膜分泌期和伴有非典型增生的子宫内膜中含量高（Ｐ＜０．０１）。结论：ＥＲ主要与子宫内膜增生过长有关，ＰＣＮＡ在非典型增生子宫内膜中过表达可能与宫内膜异常生长有关。
Objective: To explore the pathogenesis of endometrial hyperplasia and provide the theoretical basis for clinical endocrine therapy. Methods: Immunohistochemical S-P method was used to detect the contents of ER, PR and PCNA in 67 cases of endometrium and different type of hyperproliferative endometrium from different periods of surgical resection and curettage. Results: The contents of ER and PR in endometrium of normal proliferative phase were significantly higher than that in secretory phase (P <0.01). The contents of ER and PR in endometrial hyperplasia and complicated hyperplasia were also Significant difference (P <0.01). The ER levels in endometrial hyperplasia group were higher than those in PR group (P <0.01). PCNA was highly expressed in the endometrium and in the endometrium with atypical hyperplasia (P <0.01). Conclusion: ER is mainly associated with prolonged endometrial hyperplasia, and over-expression of PCNA in atypical hyperplasia may be related to abnormal endometrial growth.