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目的:探讨来氟米特治疗类风湿关节炎的疗效和不良反应。方法:选择23例类风湿关节炎患者,用来氟米特20mg/d口服,疗程为12周,比较6周和12周的疗效。结果:治疗6周时病情明显进步3例,进步3例,改善10例,总有效率为70%。12周时明显进步5例,进步9例,改善6例,总有效率为87%。5例发生不良反应(22%),表现为皮疹、白细胞下降、脱发、瘙痒,2例停药(脱落率9%)。无严重不良反应。结论:来氟米特治疗老年类风湿关节炎有效且相对安全。
Objective: To investigate the efficacy and adverse reactions of leflunomide in the treatment of rheumatoid arthritis. Methods: Twenty-three patients with rheumatoid arthritis were enrolled in this study. The patients were treated with leflunomide 20mg / d orally for 12 weeks. The curative effects of 6 weeks and 12 weeks were compared. Results: Six weeks after treatment, the condition was significantly improved in 3 cases, 3 cases improved, 10 cases improved, the total effective rate was 70%. At week 12, 5 cases were significantly improved, 9 cases improved and 6 cases improved. The total effective rate was 87%. Five patients developed adverse reactions (22%), manifested as rash, leukopenia, hair loss, pruritus, and 2 patients discontinued (shedding rate 9%). No serious adverse reactions. Conclusion: Leflunomide is effective and relatively safe for the treatment of rheumatoid arthritis in the elderly.