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三叶无患子 Sapindus trifoliatus L.(ST)果皮有多种医疗用途,但对其镇痛作用鲜有报道。作者研究了该植物水提取物对外周神经和中枢神经介导的实验性疼痛模型的镇痛作用。1)在用乙酸诱导腹部收缩前15min,给小鼠腹腔注射 ST 水提取物20和100mg/kg以及对照药吲哚美辛20mg/kg。结果显示,ST 具明显的镇痛作用,对乙酸诱导疼痛的抑制率分别为90.77%和96.26%,与吲哚美辛的作用相当。2)福尔马林可以诱导两类不同
Sapindus trifoliatus L. (ST) peel has many medical uses, but its analgesic effect is rarely reported. The authors studied the analgesic effect of this plant water extract on peripheral nerve and central nerve-mediated experimental pain models. 1) The mice were intraperitoneally injected with ST water extract 20 and 100 mg/kg and the control drug indomethacin 20 mg/kg 15 min before abdominal contraction induced by acetic acid. The results showed that ST had significant analgesic effects, and the inhibition rates for acetic acid-induced pain were 90.77% and 96.26%, respectively, which was comparable to that of indomethacin. 2) Formalin can induce two different types