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本实验采用低叶酸培养条件,对一个鼻咽癌高发家族成员和配对的正常人作了染色体畸变研究。结果:家族血缘亲属组和对照组染色体畸变率(CAR)分别为11.01％和5.06％,两者比较有高度显著性差异(P<0.001);配偶组CAR为4.6％。与对照组比较无显著性差异(P>0.25);家族中一非癌成员发现t(7;14)(P22;q22)2次,与文献报告在2例鼻咽癌患者外周血发现的染色体易位完全相同。文章讨论了染色体畸变与鼻咽癌遗传易感性的关系,认为特殊的培养条件可使家族成员CAR与正常人之间的差距加大。
In this study, low folate culture conditions, a high incidence of nasopharyngeal cancer family members and paired normal subjects made chromosome aberrations. Results: The chromosomal aberration rates (CARs) were 11.01% and 5.06% respectively in the kinship and relatives of the kinship family, with a highly significant difference (P <0.001). The CAR of the spouse was 4.6%. There was no significant difference between the control group and the control group (P> 0.25). A non-cancerous member of the family found t (7; 14) (P22; q22) The translocation is exactly the same. The article discusses the relationship between chromosomal aberrations and genetic predisposition of nasopharyngeal carcinoma, and suggests that the special culture conditions may increase the gap between family members CAR and normal individuals.