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目的：研究牛磺酸（Tau）在大鼠缺血再灌流肾损伤中的作用。方法：采用急性缺血再灌流肾损伤模型。实验分三级；对照组、单纯缺血再灌流（IR）组、牛磺酸抗缺血再港流（Tau-IR）组。结果：肾缺血再灌流24th时，IR组血肌酐（Cr）较对照组和Tau－IR组显著升高（P＜0．05＆P＜0．01），而对照组与Tau－IR组Cr无显著性差异（P＞0．05）；肾组织中LPO含量三组之间均无显著性差异；电镜检查对照组肾组织超微结构正常，Tau-IR组肾组织轻度变性，而IR组肾组织呈变性和坏死改变。结论：牛磺酸具有抗大鼠缺血再灌流性肾损伤的作用。
Objective: To study the role of taurine (Tau) in renal injury induced by ischemia-reperfusion in rats. Methods: Acute ischemia-reperfusion renal injury model was used. The experimental group was divided into three groups: control group, ischemia-reperfusion group and taurine-resistant Tau-IR group. RESULTS: Serum creatinine (Cr) in IR group was significantly higher than that in control group and Tau-IR group (P <0.05 & P <0.01) at 24th hour after ischemia and reperfusion, while Cr in control group and Tau-IR group (P> 0.05). There was no significant difference in the content of LPO between the three groups. Electron microscopy showed that the ultrastructure of renal tissue in control group was normal, and the renal tissue in Tau-IR group was slightly denatured. In IR group Renal degeneration and necrosis changes. Conclusion: Taurine has anti-ischemic reperfusion renal injury.