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目的:通过使用氘稀释法以及调查早期使用生长激素(GH)治疗在增加肌肉含量(LM)和防止均匀性肥胖方面的疗效,来评价Prader-Willi综合征(PWS)患儿的机体组分。试验设计:由11例<2岁的PWS患儿组成GH组,对他们进行为期30个月的GH治疗,6例只给予辅酶Q10治疗1年的婴幼儿组成Q10组。由95名健康儿童的资料计算得出身高校正后的LM含量(LMH1)
OBJECTIVE: To assess the body composition of children with Prader-Willi Syndrome (PWS) by using deuterium dilution and investigating the efficacy of early use of growth hormone (GH) in increasing muscle mass (LM) and preventing even obesity. Experimental Design: GH patients were enrolled in 11 children <2 years of PWS who were treated with GH for 30 months, and 6 infants and young children treated with coenzyme Q10 for 1 year to form Q10. Height-corrected LM content (LMH1) was calculated from data from 95 healthy children