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目的探讨血小板及纤维蛋白原在上皮性卵巢肿瘤中的表达及其与卵巢癌临床病理因素的关系。方法回顾性分析44例上皮性卵巢癌(EOC)患者与70例上皮性卵巢良性肿瘤患者的临床资料及病理结果,对两组患者之间及上皮性卵巢癌患者间术前血小板(PLT)及纤维蛋白原(FIB)含量进行分析比较。结果 1上皮性卵巢癌患者PLT及FIB值明显高于良性卵巢肿瘤组,两组比较,差异具有统计学意义(P<0.05),血清CA125与PLT水平、CA125与FIB水平呈正相关。2联合应用CA125+PLT或CA125+FIB提高了EOC诊断的特异度及阳性似然比。3EOC组患者PLT增多与FIGO分期、组织学分级相关(P均<0.05),与肿瘤病理类型无关;FIB增高仅与FIGO分期相关(P<0.05),与组织学分级及病理类型无关。结论联合检测CA125、PLT及FIB,可以提高EOC的术前诊断率。PLT及FIB对于卵巢癌的预后、转移的早期诊断等具有一定的临床意义。
Objective To investigate the expression of platelet and fibrinogen in epithelial ovarian tumors and its relationship with the clinicopathological factors of ovarian cancer. Methods The clinical data and pathological results of 44 patients with epithelial ovarian cancer (EOC) and 70 patients with epithelial ovarian cancer were retrospectively analyzed. The changes of preoperative PLT, Fibrinogen (FIB) content analysis and comparison. Results 1 The epithelial ovarian cancer patients with PLT and FIB values were significantly higher than the benign ovarian tumor group, the difference between the two groups was statistically significant (P <0.05), serum CA125 and PLT levels, CA125 and FIB levels were positively correlated. 2 combination of CA125 + PLT or CA125 + FIB increased the specificity and positive likelihood ratio of EOC diagnosis. The increase of PLT in 3EOC group was correlated with FIGO stage and histological grade (all P <0.05), but not with tumor pathological type. The increase of FIB was only correlated with FIGO stage (P <0.05), but not with histological grade and pathological type. Conclusions Combined detection of CA125, PLT and FIB can improve the preoperative diagnosis rate of EOC. PLT and FIB for ovarian cancer prognosis, early diagnosis of metastasis and has a certain clinical significance.