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业已证实,前列腺素在缺血性心脏综合征的发病机理中起重要作用。而消炎痛是一种强效环氧酶抑制剂,抑制血管作用的前列腺素产物,故能增加冠心病患者的冠状血管阻力。本文旨在研究消炎痛的血液动力学效应。方法:17例42—60岁患者,除2例曾有过心肌梗塞,余均经造影证实有不同程度的冠状动脉狭窄,均未使用过影响前列腺素代谢的药物,3例服
It has been demonstrated that prostaglandins play an important role in the pathogenesis of ischemic heart syndrome. Indomethacin is a potent cyclooxygenase inhibitor, a product of prostaglandins that suppresses the effects of blood vessels and therefore increases coronary vascular resistance in patients with coronary heart disease. This article aims to study the hemodynamic effects of indomethacin. Methods: Seventeen patients aged 42-60 years were divided into two groups. Except for two cases, myocardial infarction was found. All of them were confirmed by coronary angiography to have different degrees of coronary artery stenosis. None of the drugs that affect prostaglandin metabolism were used.