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目的:观察双歧杆菌三联活菌胶囊联合四磨汤口服液治疗功能性消化不良(FD)的疗效。方法:选择92例FD患者随机分为实验组和对照组各46例。对照组予以双歧杆菌三联活菌胶囊治疗,实验组在对照组治疗基础上加用四磨汤口服液。2组均治疗8周。观察临床效果及治疗前后血清P物质(SP)和一氧化氮(NO)水平的变化。结果:治疗8周后,实验组总有效率高于对照组(P<0.05)。2组血清SP水平较治疗前上升,NO水平较治疗前下降,差异均有统计学意义(P<0.05,P<0.01),实验组血清SP水平高于对照组,NO水平低于对照组,差异均有统计学意义(P<0.05)。结论:双歧杆菌三联活菌胶囊联合四磨汤口服液治疗FD的疗效较单用双歧杆菌三联活菌胶囊更佳,能明显上调血清SP,下调血清NO,从而纠正胃肠神经递质功能紊乱。
Objective: To observe the curative effect of Bifidobacterium triple viable capsule combined with Siweitang oral liquid in the treatment of functional dyspepsia (FD). Methods: 92 patients with FD were randomly divided into experimental group and control group, 46 cases each. The control group was treated with Bifidobacterium triple viable capsule. The experimental group was given Sirao Tang oral liquid on the basis of the control group. Both groups were treated for 8 weeks. To observe the clinical effects and changes of serum substance P (SP) and nitric oxide (NO) before and after treatment. Results: After 8 weeks of treatment, the total effective rate of the experimental group was higher than that of the control group (P <0.05). The levels of serum SP in the two groups increased compared with those before treatment, and the levels of NO in the two groups were significantly lower than those before treatment (P <0.05, P <0.01). The level of serum SP in the experimental group was higher than that in the control group, The differences were statistically significant (P <0.05). Conclusion: The treatment of FD with Bifidobacterium triple viable capsule combined with Siuetang Oral Liquid is better than the single Bifidobacterium triple viable capsule, which can obviously increase the serum SP and down-regulate the serum NO, so as to correct the gastrointestinal neurotransmitter function disorder.