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目的 :探讨尿激酶静脉溶栓治疗急性脑梗死的有效性、安全性及可行性。方法 :采用开放研究方法对入选病例按每公斤体重 1 5万单位尿激酶一次静脉应用 ,以后依次应用脱水剂、抗凝剂。 2 4小时后常规应用扩血管及抗凝脑保护剂 ,14天一疗程。统计溶栓后即刻有效率及一疗程时总有效率。结果 :5 0例病例溶栓后 1～ 6小时临床症状明显恢复 42例 ,即刻有效率 84% ,一疗程总有发生率 94% ,合并上消化道出血发生率 11% ,继发脑出血发生率 4% ,死亡率 6 % ,均死于并发感染及多器官功能衰竭。结论 :溶栓治疗急性脑梗死是一种安全有效的方法。
Objective: To investigate the efficacy, safety and feasibility of intravenous thrombolytic therapy for acute cerebral infarction. Methods: An open study was conducted on the selected cases of intravenous application of 15,000 units of urokinase per kilogram of body weight, followed by the application of dehydrating agent and anticoagulant. 2 4 hours after conventional application of vasodilators and anticoagulant brain protective agent, 14 days a course of treatment. Statistical thrombolysis immediately after the effective rate and the total efficiency of a course of treatment. Results: The clinical symptoms of 42 cases were recovered in 1 ~ 6 hours after thrombolysis in 50 cases. The immediate effective rate was 84%. The total incidence of one course of treatment was 94%. The incidence of upper gastrointestinal bleeding was 11%. Secondary cerebral hemorrhage occurred 4% rate, 6% mortality, all died of concurrent infection and multiple organ failure. Conclusion: Thrombolytic therapy for acute cerebral infarction is a safe and effective method.