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目的分析文献报道的乙型肝炎疫苗接种相关异常反应(Adverse events following immunization,AEFI)的一般规律及特点。方法用中文数据库检索15年来国内文献报道的乙型肝炎疫苗接种相关(疑似)AEFI病例,并进行分类统计、分析。结果乙型肝炎疫苗接种相关(疑似)AEFI的临床表现主要为过敏反应(41.13%),重组酿酒酵母乙型肝炎疫苗接种相关(疑似)AEFI病例所占比例最高(48.39%);多发生于接种后0.5～24h(35.48%)、接种后第2针(37.90%)及1岁以内的接种对象(49.19%)。结论乙型肝炎疫苗接种相关(疑似)AEFI总病例数较以往文献报道增加,但尚不能得出乙型肝炎疫苗相关(疑似)AEFI比例增多的结论,还需进一步更准确地研究分析。
Objective To analyze the general rules and characteristics of Adverse events following immunization (AEFI) reported in the literature. Methods Chinese database was used to search for 15 cases of hepatitis A virus (AEFI) -related (suspected) AEFI cases reported in domestic literature in the past 15 years, and the data were classified and analyzed statistically. Results The clinical manifestations of AEFI (suspected AEFI) were mainly anaphylactic reaction (41.13%), the highest (48.39%) was associated with suspected hepatitis A vaccine (HBeAg) After 0.5 ~ 24h (35.48%), the second needle after inoculation (37.90%) and inoculation object within 1 year old (49.19%). Conclusions The total number of AEFI related (suspected) hepatitis B vaccines has been reported more than before, but the conclusion is still not reached that the proportion of AEFI related (suspected) hepatitis B vaccine is increased.