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用一期法（ＡＰＴＴ）和合成发色底物法分别测定４５例新生儿硬肿症患者血浆凝血因子Ⅷ和抗凝血酶Ⅲ活性（ＦⅧ：ｃ和ＡＴⅢ：ａ）。结果，患者血浆ＦⅧ：ｃ和ＡＴⅢ：ａ水平明显低于正常对照组；重度硬肿二项指标明显低于轻中度硬肿；伴出血患者，二项指标明显低于无出血患者。肛温低于３６℃患者，其肛温与ＦⅧ：ｃ和ＡＴⅢ：ａ均呈显著正相关。患者凝血酶原时间（ＰＴ）、活化部分凝血活酶时间（ＡＰＴＴ）、纤维蛋白原定量（Ｆｇ）和血小板计数（ＴＣ）也有明显改变。结果显示：新生儿硬肿症多伴有凝血异常，且与硬肿症病情分度，低体温及有无出血等临床因素密切相关。提出可用血小板计数和ＦⅧ：Ｃ平行法做为新生儿硬肿症凝血异常的早期筛检指标之一及早期诊治本病的凝血机制障碍对防止或减少出血及器官衰竭的重要性。
The activity of plasma coagulation factor Ⅷ and antithrombin Ⅲ in 45 neonates with sclerema (F Ⅷ: c and AT Ⅲ: a) were determined by one-staged assay (APTT) and synthetic chromogenic substrate assay. Results: The levels of plasma FⅧ: c and ATⅢ: a in patients were significantly lower than those in normal controls. The scores of severe edema were significantly lower than those in patients with mild to moderate edema. In patients with hemorrhage, the bin index was significantly lower than those without hemorrhage. Rectal temperature below 36 ℃ patients, the rectal temperature and F Ⅷ: c and AT Ⅲ: a were significantly positive correlation. Patients’ prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen (Fg) and platelet count (TC) also changed significantly. The results showed that neonatal sclerodema often accompanied by coagulation abnormalities, and sclerosis severity index, hypothermia and with or without bleeding and other clinical factors are closely related. Proposed platelet count and F Ⅷ: C parallel method as neonatal sclerosing coagulation abnormalities one of the early screening indicators and early diagnosis and treatment of the disease coagulation disorders to prevent or reduce the importance of bleeding and organ failure.