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[目的]观察长托宁治疗急性有机磷农药中毒(AOPP)达阿托品化时的临床指标。[方法]69例急性有机磷农药中毒患者,随机分为长托宁组和阿托品组,采用推荐剂量治疗,密切观察各临床指标变化,并对其进行比较。[结果]长托宁组达到阿托品化时间较阿托品组短,口干、皮肤干燥、腺体分泌减少、肺部湿性啰音减少等同阿托品组。但瞳孔扩大、心率增快、皮肤潮红、不如阿托品明显。[结论]长托宁达阿托品化的标准以口干、皮肤黏膜干燥、心率80～90次/min为宜。
[Objective] To observe the clinical indexes of penehyclidine diazepam in the treatment of acute organophosphorus pesticide poisoning (AOPP). [Method] Sixty-nine patients with acute organophosphorus pesticide poisoning were randomly divided into two groups: chaatrolin group and atropine group. The patients were treated with the recommended dose, and the changes of each clinical index were observed and compared. [Result] The atropine group had a shorter time to atropine treatment than the atropine group, with dry mouth, dry skin, decreased glandular secretion and decreased arousal rales in the lungs. However, dilated pupils, heart rate increased, the skin flush, not as obvious as atropine. [Conclusion] The standard of Changtuo Neda Atropine is dry mouth, dry skin and mucous membrane, heart rate 80 ~ 90 times / min is appropriate.