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目的分析应用奥沙利铂联合氟尿嘧啶、亚叶酸钙辅助治疗结直肠癌术后患者共182例的临床资料。方法比较奥沙利铂联合氟尿嘧啶、亚叶酸钙方案对于结直肠癌术后化疗白细胞降低的影响。结果FOLFOX方案在结直肠癌术后辅助治疗中,50~70岁患者白细胞降低比小于50岁和大于70岁患者白细胞降低发生率少,但所有年龄段男女性别之间发生率无差别。结论奥沙利铂联合氟尿嘧啶、亚叶酸钙方案引起患者白细胞降低,在50~70岁患者间发生率更低,应用该方案对不同年龄段人群需适当调整用药方案;但对各性别组无需调整。
Objective To analyze the clinical data of 182 cases of postoperative patients with colorectal cancer treated with oxaliplatin plus fluorouracil and leucovorin. Methods The effects of oxaliplatin plus fluorouracil and leucovorin on the reduction of postoperative chemotherapy leukopenia in patients with colorectal cancer were compared. Results FOLFOX regimen in colorectal cancer postoperative adjuvant therapy, 50 to 70-year-old patients with leukopenia less than 50 years and more than 70 years of age patients with leukopenia less, but the incidence of gender differences in men and women of all ages. Conclusions Oxaliplatin combined with 5-fluorouracil and leucovorin causes the leukopenia in patients with a lower incidence among patients aged 50-70 years. The regimen should be adjusted appropriately for patients of different age groups; however, there is no need to adjust for each gender group .