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目的 :了解院内真菌感染及其药物敏感状态与疗效。方法 :对院内真菌感染危险因素、诊断及抗真菌药物敏感性进行研究。结果 :院内真菌感染 13 9例 ,占同期院内感染的 2 8 4 3 % ;感染主要部位为肺、消化道及泌尿道 ;培养出真菌 14 8株 ,白色念珠菌及热带念珠菌分别为 5 9 4 6%及 2 0 95 % ;抗真菌药物敏感性分别为AMB 5 3 90 %、 5 -FC 5 1 0 6%、KCZ 5 2 4 8%、NYS 2 8 3 7%及FCZ 61 70 % ;氟康唑治疗有效率 81 2 5 %。结论 :肺部念珠菌病最常见 ,严重基础病及长期用抗生素者发病率较高 ,治疗原发病、合理用抗生素、减少侵入性操作等有利于预防院内真菌感染 ,氟康唑治疗有效。
Objective: To understand the nosocomial fungal infection and drug sensitivity status and efficacy. Methods: The risk factors, diagnosis and antifungal susceptibility of nosocomial fungi were studied. Results: Fourteen 9 cases of nosocomial fungal infections were found, accounting for 28.43% of the nosocomial infections in the same period. The main parts of infection were lung, digestive tract and urinary tract. Fourteen 8 fungi were cultured, and Candida albicans and Candida tropicalis were 59 4 6% and 20 95% respectively. The sensitivity of antifungal drugs were AMB 5390%, 5 -FC 5 106%, KCZ 5248%, NYS 2 837% and FCZ 61 70% respectively. Fluconazole treatment efficiency 81 2 5%. Conclusions: The most common and severe basic diseases of pulmonary candidiasis and the long-term use of antibiotics are the most common diseases. The treatment of the primary disease, the rational use of antibiotics and the reduction of invasive procedures are helpful to prevent fungal infections in the hospital and fluconazole is effective.