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目的探讨还原型谷胱甘肽对肝癌肝动脉化疗栓塞(TACE)后肝脏损害的保护作用及安全性。方法 36例肝癌接受TACE后的患者被随机分为两组,治疗组予还原形谷胱甘肽,对照组给予葡萄糖醛酸内酯。治疗3周后观察患者临床症状、肝功能等的变化。结果治疗组总有效率高于对照组(P<0.05),两组均有TACE术后并发症,治疗组较对照自觉症状改善更明显,两组均无不良反应发生。结论还原型谷胱甘肽对TACE术后肝损害有较好的改善作用及安全性。
Objective To investigate the protective effect and safety of reduced glutathione on liver damage after hepatic artery chemoembolization (TACE) in patients with hepatocellular carcinoma. Methods Thirty-six patients with hepatocellular carcinoma receiving TACE were randomly divided into two groups. The treatment group was treated with reduced glutathione, and the control group with glucuronolactone. After 3 weeks of treatment, the changes of clinical symptoms and liver function were observed. Results The total effective rate in the treatment group was higher than that in the control group (P <0.05). Both groups had complications after TACE. The improvement of the symptoms in the treatment group was more obvious than that in the control group. No adverse reactions occurred in both groups. Conclusion Reduced glutathione has a good effect and safety on hepatic injury after TACE.