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目的:探讨全身炎症反应综合征(SIRS)对肝硬化患者预后的影响。方法:104例肝硬化患者根据是否合并SIRS分为SIRS组(n=25)和非SIRS组(n=79),比较两组患者入院时呼吸、脉搏、平均动脉血压、体温、肝功能Child-Pugh分级及评分、血白细胞计数(WBC)、血清丙氨酸转氨酶(ALT)、总胆红素(TBil)、白蛋白(ALB)、肌酐(Cr)、国际标准化比值(INR)、严重并发症(肝性脑病、门脉高压性出血、肝肾综合征)发生率和死亡率。结果:SIRS组患者的体温、脉搏、呼吸频率、Child-Pugh评分、血WBC、TBil、ALB、Cr、INR及住院期间的死亡率、门静脉高压性出血、肝性脑病、肝肾综合征等并发症的发生率均明显高于非SIRS组(P<0.05)。结论:合并SIRS的肝硬化患者肝功能较差、并发症多、死亡率高、预后差。
Objective: To investigate the effect of systemic inflammatory response syndrome (SIRS) on the prognosis of patients with liver cirrhosis. Methods: One hundred and four patients with cirrhosis were divided into SIRS group (n = 25) and non-SIRS group (n = 79) according to whether SIRS was merged or not.Results: Breathing, pulse, mean arterial pressure, Pugh grading and grading, WBC, ALT, TBil, ALB, creatinine (Cr), international standardization ratio (INR), severe complications (Hepatic encephalopathy, portal hypertensive hemorrhage, hepatorenal syndrome) and mortality. Results: The body temperature, pulse rate, respiratory rate, Child-Pugh score, blood WBC, TBil, ALB, Cr, INR and mortality during hospitalization, portal hypertensive hemorrhage, hepatic encephalopathy and hepatorenal syndrome in SIRS group The incidence of disease were significantly higher than non-SIRS group (P <0.05). Conclusion: Patients with cirrhosis complicated with SIRS have poor liver function, multiple complications, high mortality and poor prognosis.