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阿司匹林具有解热、镇痛及抗炎的功效,为非甾体类抗炎药[1]。目前有大量循证医学证明,阿司匹林尚具有抗血小板聚集的功能,是临床广泛应用的抗血小板及防治心脑血管事件的最佳药物之一。阿司匹林抵抗是指一些患者给予常规抗血小板聚集剂量的阿司匹林后,患者体内血小板活性不能被有效抑制的现象。阿司匹林抵抗可分为临床定义的阿司匹林抵抗、实验室定义的阿司匹林抵抗和药理学定义的阿司匹林抵抗等[2],国外研究发现阿司匹林抵抗的发生率为5%~60%[3]。
Aspirin has antipyretic, analgesic and anti-inflammatory effects, as non-steroidal anti-inflammatory drugs [1]. There is a large number of evidence-based medicine to prove that aspirin still has anti-platelet aggregation function, is widely used in clinical anti-platelet and prevention and treatment of cardiovascular and cerebrovascular events, one of the best drugs. Aspirin resistance refers to the fact that in some patients, the platelet activity in patients can not be effectively suppressed after administration of conventional anti-platelet aggregation doses of aspirin. Aspirin resistance can be divided into clinically defined aspirin resistance, aspirin resistance defined by the laboratory and pharmacologically defined aspirin resistance [2]. In foreign studies, the incidence of aspirin resistance is 5% -60% [3].